HRID971542

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1

HCID111333

N2-Benzyl p-nitrophenyl N2-carboxy-L-(2-aminoglutaramate)

C19H19N3O7

结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)OC(C)(C)C.Cl

HCID131711563

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)OCc1ccccc1

HCID131711562

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

550 mg of H-Asp(OtBu)-Phe-OCH3.HCl together with 574 mg of Z-Gln-ONP are dissolved in 2.5 ml of absolute N,N-dimethylformamide and stirred with 0.20 ml of triethylamine for 15 hours at 30°-33° C. bath temperature. Thereafter the product is extracted by shaking with a large amount of ethyl acetate as described under 19 and the solution is dried and evaporated.

WORKUP

后处理

extractionThereafter the product is extracted
customthe solution is dried
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f017a377cb684d529119602f821e0abc
来源数据集: uspto-grants-1979_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04159981
来源说明: uspto-grants-1979_07

反应 SMILES

[NH2:1][C@H:2]([C:11]([NH:13][C@H:14]([C:22]([O:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12])[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:9])([CH3:8])[CH3:7].Cl.[CH:27]1[CH:32]=[CH:31][C:30]([CH2:33][O:34][C:35]([NH:37][C@H:38]([C:44](OC2C=CC([N+]([O-])=O)=CC=2)=[O:45])[CH2:39][CH2:40][C:41]([NH2:43])=[O:42])=[O:36])=[CH:29][CH:28]=1.C(N(CC)CC)C>CN(C)C=O>[NH:37]([C:35]([O:34][CH2:33][C:30]1[CH:31]=[CH:32][CH:27]=[CH:28][CH:29]=1)=[O:36])[C@H:38]([C:44]([NH:1][C@H:2]([C:11]([NH:13][C@H:14]([C:22]([O:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:12])[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])=[O:45])[CH2:39][CH2:40][C:41](=[O:42])[NH2:43]