HCID 131711571, compound → HCID 13968094, compound

HRID 971563Notes

Reaction equation

HRID 971563 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:6]([NH:8][CH2:9][C:10]([NH:12][C@H:13]([C:15]([N:17]1[CH2:24][CH2:23][CH2:22][C@H:18]1[C:19]([NH2:21])=[O:20])=[O:16])[CH3:14])=[O:11])=[O:7])[CH:3]([CH3:5])[CH3:4].[H][H]>CO.[Pd]>[NH2:1][C@H:2]([C:6]([NH:8][CH2:9][C:10]([NH:12][C@H:13]([C:15]([N:17]1[CH2:24][CH2:23][CH2:22][C@H:18]1[C:19]([NH2:21])=[O:20])=[O:16])[CH3:14])=[O:11])=[O:7])[CH:3]([CH3:4])[CH3:5]

Participants

5

Reactant 2

HCID 131711571HCID 131711571, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13968094HCID 13968094, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.1 g of Z-Val-Gly-Ala-Pro-NH2 are dissolved in 50 ml of 80 % strength methanol and the solution is hydrogenated in the presence of 0.3 g of palladium on charcoal (10 % Pd). When the hydrogen uptake has ended the catalyst is filtered off, the solution evaporated and the residue dried in a high vacuum at 35° C. bath temperature. Hereupon the tetrapeptide H-Val-Gly-Ala-Pro-NH 2 is obtained as a colourless substance, Rf-Value = 0.20 (silica gel plates, system chloroform-methanol = 1:1).

Workup

  1. filtrationis filtered off
  2. customthe solution evaporated
  3. customthe residue dried in a high vacuum at 35° C. bath temperature

Sources & evidence

ORD record
ord-e46ab06b09c742a7bcb581a088f16b60
Source dataset
uspto-grants-1979_07
Patent number
US04159981

Reaction notes

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