HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → H-Gln-Asn-Phe-OCH3 hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Z-Gln-Asn-Phe-OCH3 | HCID 131709988 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | HCID 178418390 | HCID 178418390 | — |
| Product | H-Gln-Asn-Phe-OCH3 hydrochloride | HCID 131709989 | — |
Reaction Steps
14.1 g of Z-Gln-Asn-Phe-OCH3 are hydrogenated at 45° C. in 800 ml of methanol with the addition of 8.5 ml of 3N-hydrogen chloride in dioxan and 2.4 g of 10% palladium carbon. When the hydrogen uptake ceases, the batch is filtered and evaporated. The residue is processed without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04159981 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-677264088517493a8a4475a98d0a0625 |
| Source note | uspto-grants-1979_07 |