Hydrochloric Acid → H-Gln-Asn-Phe-OCH3 hydrochloride

HRID 971565Notes

Reaction equation

HRID 971565 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:27]([O:29][CH3:30])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])[CH2:12][C:13](=[O:15])[NH2:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[ClH:41]>CO.O1CCOCC1.[C].[Pd]>[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:27]([O:29][CH3:30])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])[CH2:12][C:13](=[O:15])[NH2:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[ClH:41]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 131709988Z-Gln-Asn-Phe-OCH3

Product 1

HCID 131709989H-Gln-Asn-Phe-OCH3 hydrochloride

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 312751,4-DioxaneSolventHCID 178418390HCID 178418390, compoundSolvent

Procedure

14.1 g of Z-Gln-Asn-Phe-OCH3 are hydrogenated at 45° C. in 800 ml of methanol with the addition of 8.5 ml of 3N-hydrogen chloride in dioxan and 2.4 g of 10% palladium carbon. When the hydrogen uptake ceases, the batch is filtered and evaporated. The residue is processed without purification.

Workup

  1. filtrationWhen the hydrogen uptake ceases, the batch is filtered
  2. customevaporated
  3. customThe residue is processed without purification

Sources & evidence

ORD record
ord-677264088517493a8a4475a98d0a0625
Source dataset
uspto-grants-1979_07
Patent number
US04159981

Reaction notes

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