Ammonia → HCID 21313191, compound

HRID 971629Notes

Reaction equation

HRID 971629 reaction equation
Cl[C:2]1[CH:7]=[N:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][N:3]=1.[NH3:17].[OH-].[NH4+]>>[NH2:17][C:2]1[CH:7]=[N:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 14923Ammonium HydroxideHCID 20567060HCID 20567060, compound

Product 1

HCID 21313191HCID 21313191, compound

Procedure

The 2-chloro-5-phenylsulfonylpyrazine can then be allowed to react with ammonia or ammonium hydroxide in a high pressure reaction vessel, at a temperature of about 100° to about 200° C. to yield the 2-amino-5-phenylsulfonylpyrazine intermediate. Reaction conditions may vary depending on the chemical structure of the phenylsulfonyl grouping.

Sources & evidence

ORD record
ord-e902f4a8afd442f09fd3e954b3f7d31b
Source dataset
uspto-grants-1979_07
Patent number
US04160834

Reaction notes

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