Hydrogen Bromide → HCID 21312053, compound

HRID 971847Notes

Reaction equation

HRID 971847 reaction equation
[BrH:1].O[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1>>[ClH:12].[Br:1][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 12296176N-(2-hydroxyethyl)-3-chloroaniline

Product 1

HCID 21312053HCID 21312053, compoundYield 146.7%

Conditions

Temperature
124 °C

Procedure

50 gm of 50% hydrobromic acid were slowly added dropwise to 19 gm of the product obtained in step (a), while stirring. The vessel containing the resulting mixture was then connected to a Vigreux-column, and the mixture was heated until a temperature of about 124° C. was reached. After three hours of heating at that temperature, about 35 ml of liquid were distilled off. The residue solidified upon cooling and was purified by washing with acetone, yielding 22 gm of the desired product which had a melting point of 148° C.

Workup

  1. additionThe vessel containing the resulting mixture
  2. distillationwere distilled off
  3. temperatureupon cooling
  4. customwas purified
  5. washby washing with acetone

Sources & evidence

ORD record
ord-83b0134809ae452fa16118b493989fcc
Source dataset
uspto-grants-1979_07
Patent number
US04161528

Reaction notes

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