反应详情

温度

50 °C

A mixture of 995.0 g of 5-isopropylhydantoin (7 mols), 2000 ml of dimethylformamide and 14.8 g of lithium chloride is stirred at 50° C. 1220 g of propene oxide (21 mols) are slowly added dropwise over the course of 6 hours. Thereafter the temperature is gradually raised at 70° C. and after a total of 15 hours the reaction mixture is allowed to cool. It is adjusted to pH = 7 with a few drops of 2 N H2SO4 and the pale yellow solution is filtered. The solution is completely concentrated at 90° C. bath temperature on a rotational evaporator under a waterpump vacuum and is subsequently treated at 90° C./0.1 mm Hg until constant weight is reached. 1654.5 g of a pale yellow highly viscous product (91.7% of theory) are obtained.

1. temperatureThereafter the temperature is gradually raised at 70° C.
2. customafter a total of 15 hours
3. temperatureto cool
4. filtrationthe pale yellow solution is filtered
5. concentrationThe solution is completely concentrated at 90° C. bath temperature
6. customon a rotational evaporator under a waterpump vacuum
7. additionis subsequently treated at 90° C./0.1 mm Hg until constant weight
8. custom1654.5 g of a pale yellow highly viscous product (91.7% of theory) are obtained