HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxynaltrexone → Naltrexone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxynaltrexone | HCID 5487695 | — |
| Reactant | (-)-3-Methoxy-6-oxo Butorphanol | HCID 57257006 | — |
| Reactant | N-cyclopropylmethyl-3-methoxy-14-hydroxymorphinan | HCID 70587809 | — |
| Product | Naltrexone | HCID 5360515 | — |
| Product | Oxilorphan | HCID 5361090 | — |
| Product | 6-Oxo (-)-Butorphanol | HCID 57088644 | — |
Reaction Steps
In accordance with the above procedure, but starting, in place of N-cyclobutylmethylnoroxycodone, with N-cyclopropylmethylnoroxycodone (6a), N-ethylnoroxycodone (6c), N-cyclopropylmethyl-3-methoxy-14-hydroxymorphinan (6e), or N-cyclobutylmethyl-3-methoxy-14-hydroxy-6-oxomorphinan (6f), there is obtained the corresponding N-cyclopropylmethylnoroxymorphone (7a), N-ethylnoroxymorphone (7c), N-cyclopropylmethyl-3,14-dihydroxymorphinan (7e) or N-cyclobutylmethyl-3,14-dihydroxy-6-oxomorphinan (7f).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04161597 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-cebc1ec4a2e44d4098f1852fd0a5ec36 |
| Source note | uspto-grants-1979_07 |