HCID 21311664, compound → N-[(2-Oxopyrrolidin-1-yl)acetyl]glycine

HRID 971988Notes

Reaction equation

HRID 971988 reaction equation
C([O:8][C:9](=[O:21])[CH2:10][NH:11][C:12](=[O:20])[CH2:13][N:14]1[CH2:18][CH2:17][CH2:16][C:15]1=[O:19])C1C=CC=CC=1>C(O)(=O)C.[Pd]>[O:19]=[C:15]1[CH2:16][CH2:17][CH2:18][N:14]1[CH2:13][C:12]([NH:11][CH2:10][C:9]([OH:21])=[O:8])=[O:20]

Participants

4

Reactant 1

HCID 21311664HCID 21311664, compound2×

Product 1

HCID 14672926N-[(2-Oxopyrrolidin-1-yl)acetyl]glycineYield 100%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 23938PalladiumSolvent

Procedure

2.9 g (0.01 mole) of N-(2-oxo-1-pyrrolidineacetyl)-glycine benzyl ester (compound 1.b) above) are dissolved in 50 ml of acetic acid and hydrogenated in the presence of palladium supported on carbon (Pd/C) at ambient temperature, under a hydrogen pressure of 4 kg. The catalyst is filtered off, the filtrate is evaporated to dryness and the syrup obtained is triturated with anhydrous diethyl ether, a white powder being obtained: 2 g of N-(2-oxo-1-pyrrolidineacetyl)-glycine are thus isolated; M.P. 149°-150° C. Yield: 100% of theory.

Workup

  1. customsupported on carbon (Pd/C) at ambient temperature, under a hydrogen
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated to dryness
  4. customthe syrup obtained
  5. customis triturated with anhydrous diethyl ether
  6. customa white powder being obtained

Sources & evidence

ORD record
ord-dbfdd2e7e7584232a0e630c02b012dce
Source dataset
uspto-grants-1979_07
Patent number
US04162325

Reaction notes

Loading…