HCID 21311664, compound → N-[(2-Oxopyrrolidin-1-yl)acetyl]glycine

Participants

Reaction Steps

2.9 g (0.01 mole) of N-(2-oxo-1-pyrrolidineacetyl)-glycine benzyl ester (compound 1.b) above) are dissolved in 50 ml of acetic acid and hydrogenated in the presence of palladium supported on carbon (Pd/C) at ambient temperature, under a hydrogen pressure of 4 kg. The catalyst is filtered off, the filtrate is evaporated to dryness and the syrup obtained is triturated with anhydrous diethyl ether, a white powder being obtained: 2 g of N-(2-oxo-1-pyrrolidineacetyl)-glycine are thus isolated; M.P. 149°-150° C. Yield: 100% of theory.

Provenance & Evidence