1-Cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl]piperazine → HCID 131711582, compound

HRID 971998Notes

Reaction equation

HRID 971998 reaction equation
C1([N:7]2[CH2:12][CH2:11][N:10](C(C3C=CC=CC=3)CC3C=C(C)C=CC=3)[CH2:9][CH2:8]2)CCCCC1.[OH2:28].[C:29]([C@:37]([C:52]([OH:54])=[O:53])([OH:51])[C@:38]([C:43](=[O:50])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)([OH:42])[C:39]([OH:41])=[O:40])(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>C(O)C>[OH2:36].[C:43]([C@:38]([C:39]([OH:41])=[O:40])([OH:42])[C@:37]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:51])[C:52]([OH:54])=[O:53])(=[O:50])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1.[NH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[OH2:28].[OH2:36].[NH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:43]([C@:38]([C:39]([OH:41])=[O:40])([OH:42])[C@:37]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:51])[C:52]([OH:54])=[O:53])(=[O:50])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1

Participants

4

Reactant 2

HCID 124668821-Cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl]piperazineHCID 122598382Dibezoyl-D-tartaric acid monohydrate

Product 1

HCID 131711582HCID 131711582, compoundYield 59.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A warmed mixture of dl-1-cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl]piperazine (3.0 g), dibenzoyl-d-tartaric acid monohydrate (3.2 g) and ethanol (100 ml) is allowed to cool. The precipitated crystals are separated by filtration and fractionally recrystallized from 95% ethanol to give l-1-cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl[piperazine dibenzoyl-d-tartarate sesquihydrate (1.2 g), melting point: 150°- 151° C. (decomp.), [α D28 = -83.0° (c=1.0, methanol).

Workup

  1. temperatureto cool
  2. customThe precipitated crystals are separated by filtration
  3. customfractionally recrystallized from 95% ethanol

Sources & evidence

ORD record
ord-c3452cb47e8049b39da8c42560e21de6
Source dataset
uspto-grants-1979_07
Patent number
US04162316

Reaction notes

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