HRID971998

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cccc(CC(c2ccccc2)N2CCN(C3CCCCC3)CC2)c1

HCID12466882

未命名化合物

结构：O.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1

HCID122598382

未命名化合物

PRODUCTS

生成物

结构：C1CNCCN1.C1CNCCN1.O.O.O.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1.O=C(O)[C@](O)(C(=O)c1ccccc1)[C@](O)(C(=O)O)C(=O)c1ccccc1

HCID131711582

未命名化合物

收率 59.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A warmed mixture of dl-1-cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl]piperazine (3.0 g), dibenzoyl-d-tartaric acid monohydrate (3.2 g) and ethanol (100 ml) is allowed to cool. The precipitated crystals are separated by filtration and fractionally recrystallized from 95% ethanol to give l-1-cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl[piperazine dibenzoyl-d-tartarate sesquihydrate (1.2 g), melting point: 150°- 151° C. (decomp.), [α D28 = -83.0° (c=1.0, methanol).

WORKUP

后处理

temperatureto cool
customThe precipitated crystals are separated by filtration
customfractionally recrystallized from 95% ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c3452cb47e8049b39da8c42560e21de6
来源数据集: uspto-grants-1979_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04162316
来源说明: uspto-grants-1979_07

反应 SMILES

C1([N:7]2[CH2:12][CH2:11][N:10](C(C3C=CC=CC=3)CC3C=C(C)C=CC=3)[CH2:9][CH2:8]2)CCCCC1.[OH2:28].[C:29]([C@:37]([C:52]([OH:54])=[O:53])([OH:51])[C@:38]([C:43](=[O:50])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)([OH:42])[C:39]([OH:41])=[O:40])(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>C(O)C>[OH2:36].[C:43]([C@:38]([C:39]([OH:41])=[O:40])([OH:42])[C@:37]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:51])[C:52]([OH:54])=[O:53])(=[O:50])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1.[NH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[OH2:28].[OH2:36].[NH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:43]([C@:38]([C:39]([OH:41])=[O:40])([OH:42])[C@:37]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:51])[C:52]([OH:54])=[O:53])(=[O:50])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1