HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 12814740, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-(N-methylanilino)propan-2-one | HCID 458699 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 70613586 | HCID 70613586 | — |
| Product | HCID 12814740 | HCID 12814740 | — |
Reaction Steps
To To a solution of 20 mmol 5-(2-amino-hydroxyethyl)salicylamide and 3.26 g (20 mmol) N-methylanilino acetone in 100 ml methanol add 2.51 g (40 mmol) NaCNBH3. Stir 16 hrs., concentrate, and partition between EtOAc and 1.0 N NaHCO3 solution. Dry and concentrate the organic layer. Dissolve the foam in CHCl3, and wash with water. Filter the solid which forms and recrystallize from EtOAc to give a white solid, mp 143°-5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04163053 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-4c7dec0d11964136a92689c4decdd1cc |
| Source note | uspto-grants-1979_07 |