反应详情

To To a solution of 20 mmol 5-(2-amino-hydroxyethyl)salicylamide and 3.26 g (20 mmol) N-methylanilino acetone in 100 ml methanol add 2.51 g (40 mmol) NaCNBH3. Stir 16 hrs., concentrate, and partition between EtOAc and 1.0 N NaHCO3 solution. Dry and concentrate the organic layer. Dissolve the foam in CHCl3, and wash with water. Filter the solid which forms and recrystallize from EtOAc to give a white solid, mp 143°-5°.

1. concentration, concentrate
2. custompartition between EtOAc and 1.0 N NaHCO3 solution
3. customDry
4. concentrationconcentrate the organic layer
5. dissolutionDissolve the foam in CHCl3
6. washwash with water
7. filtrationFilter the solid which forms
8. customrecrystallize from EtOAc
9. customto give a white solid, mp 143°-5°