4-Iodotoluene → 5-Methyl-1-p-tolyl-2-(1H)-pyridone

HRID 972308Notes

Reaction equation

I[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.[CH3:9][C:10]1[CH:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=1>>[CH3:9][C:10]1[CH:11]=[CH:12][C:13](=[O:16])[N:14]([C:2]2[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=2)[CH:15]=1

Participants

Reactant 2

HCID 122074-Iodotoluene

HCID 704822-Hydroxy-5-methylpyridine

Product 1

HCID 103135445-Methyl-1-p-tolyl-2-(1H)-pyridoneYield 89%

Procedure

The reaction of p-iodotoluene with 5-methyl-2-(1H)-pyridone by the procedure of Example 1, affords 5-Methyl-1-p-tolyl-2-(1H)-pyridone in 89% yield.

Sources & evidence

ORD record: ord-d8de92a45cee4bf5ab1870deb6fa7693
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04052509

Reaction notes

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