Homoveratrylamine → HCID 21406686, compound

HRID 972345Notes

Reaction equation

HRID 972345 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:14][C:15]1[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=1[CH:17]1[O:19][CH2:18]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13][CH2:18][CH:17]([OH:19])[C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[CH3:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 8421HomoveratrylamineHCID 1510422-(2-Methylphenyl)oxirane

Product 1

HCID 21406686HCID 21406686, compound

Procedure

Similarly a mixture of 13.6 g. (0.0753 mol) of 3,4-dimethoxyphenylethylamine and 10.1 g. (0.753 mol) of o-methylstyrene oxide is stirred at 100° C. under argon for 16 hours to yield N-[2-(3,4-dimethoxyphenyl)ethyl]-2-hydroxy-2-(2-methylphenyl)ethylamine, m.p. 91°-94° C.

Workup

  1. additionSimilarly a mixture of 13.6 g

Sources & evidence

ORD record
ord-8c9bb0fb165049e58bbf6b5b983a3ecd
Source dataset
uspto-grants-1977_10
Patent number
US04052506

Reaction notes

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