Sodium Hydroxide → HCID 21406751, compound

HRID 972359Notes

Reaction equation

HRID 972359 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9](N)=[O:10])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=1[F:19].[OH-:20].[Na+]>O>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9]([OH:20])=[O:10])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=1[F:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54325586HCID 54325586, compound

Product 1

HCID 21406751HCID 21406751, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2,2',4'-trifluoro-4-biphenylylacetamide (100 mg.), aqueous caustic soda (18N; 1 ml.) and water (5 ml.) was stirred under reflux overnight. The mixture was acidified and extracted with ether. The ether was evaporated and the product recrystallised from 80-100 petroleum ether to give 2,2',4'-trifluoro-4-biphenylylacetic acid, m.p. 144°-147° C.

Workup

  1. temperatureunder reflux overnight
  2. extractionextracted with ether
  3. customThe ether was evaporated
  4. customthe product recrystallised from 80-100 petroleum ether

Sources & evidence

ORD record
ord-7f687811921f4d83968defcb73d9d3e3
Source dataset
uspto-grants-1977_10
Patent number
US04052514

Reaction notes

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