Hydroxylamine → HCID 21406762, compound

HRID 972362Notes

Reaction equation

HRID 972362 reaction equation
[NH2:1][OH:2].[F:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11](Cl)=[O:12])[CH:7]=[CH:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21]>CCOCC.O>[F:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11]([NH:1][OH:2])=[O:12])[CH:7]=[CH:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21]

Participants

5

Reactant 2

HCID 787HydroxylamineHCID 53967044HCID 53967044, compound

Product 1

HCID 21406762HCID 21406762, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent2×

Procedure

Hydroxylamine free base was added to a solution of 2,2',4'-trifluoro-4-biphenylylacetyl chloride (obtained as in Example 9) in ether. After stirring for 15 minutes the ether solution was diluted with water, separated, washed again with water, dried and evaporated. The orange residue was recrystallised twice from acetone/40-60 petroleum ether and then from toluene to give fine colourless needles of 2,2',4'-trifluoro-4-biphenylylacethydroxamic acid, m.p. 149°-150° C.

Workup

  1. customseparated
  2. washwashed again with water
  3. customdried
  4. customevaporated
  5. customThe orange residue was recrystallised twice from acetone/40-60 petroleum ether

Sources & evidence

ORD record
ord-c2d07ca6948e4c2580ef71a4e07f3615
Source dataset
uspto-grants-1977_10
Patent number
US04052514

Reaction notes

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