HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(1,1-dimethyl-2-hydroxyethyl)-5-nitro-2,3-dihydro-1H-isoindol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | 4-Nitrophthalic acid anhydride | HCID 230976 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(1,1-dimethyl-2-hydroxyethyl)-5-nitro-2,3-dihydro-1H-isoindol | HCID 21988156 | — |
Reaction Steps
20 g of 4-Nitro-phthalic anhydride and 8.94 g of 2-amino-2-methylpropanol were heated to 170° C. for 30 min. After cooling, water and CH2Cl2 were added, and the organic phase separated, concentrated and purified by chromatography on silica (eluent CH2Cl2/MeOH 97/3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091345B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-a28dfc986e8549b3bda0a7e2c9a0bc50 |
| Source note | uspto-grants-2006_08 |