Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | 2-[3-(Dimethylamino)propoxy]benzaldehyde | HCID 2995968 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 20394044 | HCID 20394044 | 74.8% |
Reaction Steps
A solution of 32.5 g of 2-(3-dimethylaminopropoxy)benzaldehyde and 18.9 g of phenethylamine in 150 ml of toluene is heated at reflux for 1 hour. After 30 minutes, one mole equivalent of water is collected in a Dean-Stark trap. After cooling to approximately 50° C., the solvent is removed using a rotary evaporator and the oily residue is distilled to give 36.2 g of the title compound, boiling point 165°-167° C. at 0.05 mm of Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04053471 |
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| Source dataset | uspto-grants-1977_10 |
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| ORD ID | ord-b65475d9d3724a059dd2988084306063 |
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| Source note | uspto-grants-1977_10 |
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