HCID 54293063, compound → HCID 21404648, compound

HRID 972478Notes

Reaction equation

HRID 972478 reaction equation
[CH3:1][N:2]([CH2:30][CH3:31])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH:13]1[N:17]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-])=O)=[CH:22][CH:21]=2)[C:16](=[O:29])[CH2:15][S:14]1.[H][H]>C(O)C.[Pd]>[CH3:1][N:2]([CH2:30][CH3:31])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH:13]1[N:17]([CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][C:23]([NH2:26])=[CH:24][CH:25]=2)[C:16](=[O:29])[CH2:15][S:14]1

Participants

5

Reactant 2

HCID 54293063HCID 54293063, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21404648HCID 21404648, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 10 parts of 2-[2-[3-(methylethylamino)propoxy]phenyl]-3-[2-(4-nitrophenyl)ethyl]-4-thiazolidinone (see Example 19) in 100 ml of ethanol is treated with 1 part of 5% palladium on carbon and placed under 3 atmospheres of gaseous hydrogen. The mixture is shaken until one equivalent of hydrogen is consumed, filtered and the solvent evaporated under reduced pressure to give the title compound.

Workup

  1. customis consumed
  2. filtrationfiltered
  3. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-b21a94b064df4707b669617d59f895bb
Source dataset
uspto-grants-1977_10
Patent number
US04053471

Reaction notes

Loading…