Sodium Hydroxide → N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea

HRID 972521Notes

Reaction equation

HRID 972521 reaction equation
C([NH:9][C:10]([NH:12][CH:13]1[C:21]2[CH:20]=[CH:19][S:18][C:17]=2[CH2:16][CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>>[S:18]1[CH:19]=[CH:20][C:21]2[CH:13]([NH:12][C:10]([NH2:9])=[O:11])[CH2:14][CH2:15][CH2:16][C:17]1=2

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 130370061-Benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl)urea

Product 1

HCID 13036998N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea

Procedure

A mixture of 1-benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl) urea and 2N aqueous sodium hydroxide solution (5ml) is stirred at reflux for 2.5 hours. The mixture is cooled in ice, the product is collected and washed with water to afford 0.58 g of title compound, m.p. 203° to 207° C.

Workup

  1. temperatureat reflux for 2.5 hours
  2. temperatureThe mixture is cooled in ice
  3. customthe product is collected
  4. washwashed with water

Sources & evidence

ORD record
ord-14391dd763914b96a03eb547db6e1b88
Source dataset
uspto-grants-1977_10
Patent number
US04053484

Reaction notes

Loading…