反应详情

A mixture of N-(4,5,6,7-tetrahydro-7-oxobenzo[b]-thien-4-yl)acetamide (16.0 g), water (100 ml) and concentrated hydrochloric acid (100 ml) is stirred and heated at reflux for an overnight period. The mixture is cooled, made alkaline with 50% aqueous sodium hydroxide, and sautrated with sodium chloride. The mixture is then extracted with methylene chloride (3×250 ml). The extracts are combined, dried over magnesium sulfate and then evaporated to dryness in vacuo to afford the title compound as a yellow-brown syrup.

1. temperatureheated
2. temperatureat reflux for an overnight period
3. temperatureThe mixture is cooled
4. extractionThe mixture is then extracted with methylene chloride (3×250 ml)
5. dry with materialdried over magnesium sulfate
6. customevaporated to dryness in vacuo