Ethylene Glycol → 3-(2-Hydroxyethoxymethyl)pyrazole

HRID 972573Notes

Reaction equation

Cl[CH2:2][C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.OCC1C=CNN=1.[Na].[CH2:16]([OH:19])[CH2:17][OH:18]>>[OH:18][CH2:17][CH2:16][O:19][CH2:2][C:3]1[CH:7]=[CH:6][NH:5][N:4]=1

Participants

Reactant 4

HCID 174Ethylene Glycol

HCID 5360545Sodium

HCID 178478439HCID 178478439, compound

HCID 178519763HCID 178519763, compound

Product 1

HCID 1785214303-(2-Hydroxyethoxymethyl)pyrazole

Procedure

3-Chloromethylpyrazole, prepared by reacting 3-hydroxymethylpyrazole witth thionyl chloride, is reacted with the sodium salt of ethylene glycol to give 3-(2-hydroxyethoxymethyl)pyrazole. Treatment of 3-(2-hydroxyethoxymethyl)pyrazole with thionyl chloride gives 3-(2-chloroethoxymethyl)pyrazole.

Sources & evidence

ORD record: ord-b7530013ac0345218c17a6b903a8a388
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04053473

Reaction notes

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