反应详情

A solution of 1120 g. of N-methylpiperazine and 755 g. of p-fluoroacetophenone in 1920 ml. of dimethyl-sulfoxide is heated at 95° for 16 hours, then evaporated at reduced pressure. The residue is poured into 8 liters of water and the solution is basified with 440 g. of 50% aqueous sodium hydroxide and cooled. The precipitate of p-(4-methyl-1-piperazinyl)acetophenone is collected by filtration, washed with water and dried; m.p. 97°-99°.

1. customevaporated at reduced pressure
2. additionThe residue is poured into 8 liters of water
3. temperatureof 50% aqueous sodium hydroxide and cooled
4. filtrationThe precipitate of p-(4-methyl-1-piperazinyl)acetophenone is collected by filtration
5. washwashed with water
6. customdried