反应详情

A mixture of 33.2 g. of p-fluoroacetophenone, 48.3 g. of N-propylpiperazine and 99.5 g. of potassium carbonate in 100 ml. of dimethyl sulfoxide is stirred and heated at 95° for 4.5 hours, then cooled and poured into ice water. The precipitate of p-(4-propyl-1-piperazinyl)-acetophenone is collected by filtration, washed with water and dried; m.p. 68°-70° after crystallization from hexane.

1. additionA mixture of 33.2 g
2. temperatureheated at 95° for 4.5 hours
3. temperaturecooled
4. filtrationThe precipitate of p-(4-propyl-1-piperazinyl)-acetophenone is collected by filtration
5. washwashed with water
6. customdried
7. customm.p. 68°-70° after crystallization from hexane