Sodium Hydroxide → 56915-77-6

HRID 972678Notes

Reaction equation

HRID 972678 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[OH-].[Na+]>O>[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8](=[O:10])[CH3:9])[CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 531671-MethylpiperazineHCID 96744o-Fluoroacetophenone

Product 1

HCID 2140456756915-77-6

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 55.2 g. of o-fluoroacetophenone and 100 ml. of N-methyl-piperazine is heated at 95°-100° for 19 hours, then cooled and poured into 1600 ml. of water containing 22 ml. of 50% aqueous sodium hydroxide. The mixture is extracted with three 300 ml. portions of ether. The combined ether extract is washed thoroughly with water, then with saturated aqueous sodium chloride, dried and evaporated to give o-(4-methyl-1-piperazinyl)acetophenone as a viscous oil, suitable for use without further purification.

Workup

  1. additionA mixture of 55.2 g
  2. temperaturecooled
  3. additionpoured into 1600 ml
  4. extractionThe mixture is extracted with three 300 ml
  5. extractionThe combined ether extract
  6. washis washed thoroughly with water
  7. dry with materialwith saturated aqueous sodium chloride, dried
  8. customevaporated

Sources & evidence

ORD record
ord-d56ad56f49b249ee903f0b0ef96db778
Source dataset
uspto-grants-1977_10
Patent number
US04053470

Reaction notes

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