Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | 3-Chloro-2,4-pentanedione | HCID 74328 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178433499 | HCID 178433499 | — |
Reaction Steps
A solution of 134.5 g (1 mole) of the 3-chloropentane-2,4-dione prepared as in (i) and 75 g (1.25 moles) of urea in 800 ml of ethanol and 100 ml of concentrated hydrochloric acid was heated for 10 hours under reflux. It was then cooled to -10° C., whereupon a precipitate formed, which was filtered off and dried. 114 g (58% of theory of 2-hydroxy-5-chloro-4,6-dimethylpyrimidine hydrochloride were obtained in the form of colorless crystals of melting point >210° C. ##STR57##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04053594 |
|---|
| Source dataset | uspto-grants-1977_10 |
|---|
| ORD ID | ord-581888e0fda144c7bd0f94d2ea7ca931 |
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| Source note | uspto-grants-1977_10 |
|---|
