Urea → HCID 178433499, compound

HRID 972708Notes

Reaction equation

HRID 972708 reaction equation
[Cl:1][CH:2]([C:6](=O)[CH3:7])[C:3](=O)[CH3:4].[NH2:9][C:10]([NH2:12])=[O:11]>C(O)C.Cl>[ClH:1].[OH:11][C:10]1[N:12]=[C:6]([CH3:7])[C:2]([Cl:1])=[C:3]([CH3:4])[N:9]=1

Participants

5

Reactant 2

HCID 1176UreaHCID 743283-Chloro-2,4-pentanedione

Product 1

HCID 178433499HCID 178433499, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Conditions

Temperature
-10 °C

Procedure

A solution of 134.5 g (1 mole) of the 3-chloropentane-2,4-dione prepared as in (i) and 75 g (1.25 moles) of urea in 800 ml of ethanol and 100 ml of concentrated hydrochloric acid was heated for 10 hours under reflux. It was then cooled to -10° C., whereupon a precipitate formed, which was filtered off and dried. 114 g (58% of theory of 2-hydroxy-5-chloro-4,6-dimethylpyrimidine hydrochloride were obtained in the form of colorless crystals of melting point >210° C. ##STR57##

Workup

  1. temperaturewas heated for 10 hours
  2. temperatureunder reflux
  3. customformed
  4. filtrationwhich was filtered off
  5. customdried

Sources & evidence

ORD record
ord-581888e0fda144c7bd0f94d2ea7ca931
Source dataset
uspto-grants-1977_10
Patent number
US04053594

Reaction notes

Loading…