HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 1-(2-Fluorobenzyl)-2-[alpha-(4-methylpiperazino)-acetyl]pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2-Chloro-1-{1-[(2-fluorophenyl)methyl]-1H-pyrrol-2-yl}ethan-1-one | HCID 20391531 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(2-Fluorobenzyl)-2-[alpha-(4-methylpiperazino)-acetyl]pyrrole | HCID 21405113 | — |
Reaction Steps
A mixture of 2-chloroacetyl-1-(2-fluorobenzyl)pyrrole Example 1a, N-methylpiperazine and triethylamine in methaol is treated by the procedure described in Example 1b to produce 1-(2-fluorobenzyl)-2-[α-(4-methylpiperazino)-acetyl]pyrrole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04053599 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-d0b112eae3a541828be80fae1216d5b9 |
| Source note | uspto-grants-1977_10 |