1-Methylpiperazine → 1-(2-Fluorobenzyl)-2-[alpha-(4-methylpiperazino)-acetyl]pyrrole

HRID 972737Notes

Reaction equation

HRID 972737 reaction equation
Cl[CH2:2][C:3]([C:5]1[N:6]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[CH:7]=[CH:8][CH:9]=1)=[O:4].[CH3:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>C(N(CC)CC)C>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:10][N:6]1[CH:7]=[CH:8][CH:9]=[C:5]1[C:3](=[O:4])[CH2:2][N:22]1[CH2:23][CH2:24][N:19]([CH3:18])[CH2:20][CH2:21]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 203915312-Chloro-1-{1-[(2-fluorophenyl)methyl]-1H-pyrrol-2-yl}ethan-1-one

Product 1

HCID 214051131-(2-Fluorobenzyl)-2-[alpha-(4-methylpiperazino)-acetyl]pyrrole

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A mixture of 2-chloroacetyl-1-(2-fluorobenzyl)pyrrole Example 1a, N-methylpiperazine and triethylamine in methaol is treated by the procedure described in Example 1b to produce 1-(2-fluorobenzyl)-2-[α-(4-methylpiperazino)-acetyl]pyrrole.

Workup

  1. additionis treated by the procedure

Sources & evidence

ORD record
ord-d0b112eae3a541828be80fae1216d5b9
Source dataset
uspto-grants-1977_10
Patent number
US04053599

Reaction notes

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