Hydrazine hydrate (1:1) → HCID 20309600, compound

HRID 972763Notes

Reaction equation

HRID 972763 reaction equation
[OH:1][CH:2]([CH2:18][NH:19][CH:20]([CH3:22])[CH3:21])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:12]=[CH:13][C:14](=S)[NH:15][N:16]=1.O.[NH2:24][NH2:25]>>[NH:24]([C:14]1[N:15]=[N:16][C:11]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]([OH:1])[CH2:18][NH:19][CH:20]([CH3:22])[CH3:21])=[CH:12][CH:13]=1)[NH2:25]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20309611HCID 20309611, compound

Product 1

HCID 20309600HCID 20309600, compound

Procedure

A stirred mixture of 6-[2-(2-hydroxy-3-isopropylaminopropoxy)phenyl]-3(2H)-pyridazinethione (1.5 g, 0.005 mole) and hydrazine hydrate (30 ml) was heated under reflux in an atmosphere of nitrogen for 90 minutes. Excess of hydrazine hydrate was removed under reduced pressure to give 3-hydrazino-6-[2-(2-hydroxy-3-isopropylaminopropoxy)phenyl]-pyridazine as an oil which was converted into an amorphous citrate (2 g, 83%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux in an atmosphere of nitrogen for 90 minutes
  3. customExcess of hydrazine hydrate was removed under reduced pressure

Sources & evidence

ORD record
ord-40ed0f7617ef4793bb8d4c924e4c2cc2
Source dataset
uspto-grants-1977_10
Patent number
US04053601

Reaction notes

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