Tert-Butylamine → HCID 20309571, compound

HRID 972767Notes

Reaction equation

[O:1]1[CH2:20][CH:2]1[CH2:3][O:4][C:5]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:6]=1[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8].[C:21]([NH2:25])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([NH:25][CH2:20][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:6]=1[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:24])([CH3:23])[CH3:22]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 20309544HCID 20309544, compound

Product 1

HCID 20309571HCID 20309571, compound

Procedure

Methyl 3-[2-(2,3-epoxypropoxy)-4-methylbenzoyl]-propionate was treated with t-butylamine in a similar manner to the procedure described in Example 2(i) to give methyl 3-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methylbenzoyl]-propionate, m.p. 82°-84.5°.

Sources & evidence

ORD record: ord-b13fae4c61494b6384f43f83c42e4066
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04053601

Reaction notes

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