Tert-Butylamine → HCID 21246153, compound

HRID 972775Notes

Reaction equation

HRID 972775 reaction equation
[O:1]1[CH2:21][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[C:13]1[N:18]=[N:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1.[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23]>CO>[C:22]([NH:26][CH2:21][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[C:13]1[N:18]=[N:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)([CH3:25])([CH3:24])[CH3:23]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 21405167HCID 21405167, compound

Product 1

HCID 21246153HCID 21246153, compoundYield 71.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 6-[2-(2,3-epoxypropoxy)-4-methoxyphenyl]-3-methoxypyridazine (0.7 g, 0.0024 mole), t-butylamine (10.0 ml, 0.093 mole) in methanol (20 ml) was allowed to stand at room temperature for 24 hours. Evaporation of the solvent and crystallisation of the residue from ethyl acetate gave 6-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-3-methoxypyridazine (0.62 g, 70%, m.p. 114°-116°).

Workup

  1. customEvaporation of the solvent and crystallisation of the residue from ethyl acetate

Sources & evidence

ORD record
ord-57e5017d6c8b4d14b5cb51b9365abdbf
Source dataset
uspto-grants-1977_10
Patent number
US04053601

Reaction notes

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