Potassium Carbonate → HCID 13023013, compound

HRID 972777Notes

Reaction equation

HRID 972777 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11](OC)=[CH:10][C:9]=2[OH:16])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:23]([CH:25]1[O:27][CH2:26]1)Br>CC(=O)CC>[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:16][CH2:23][CH:25]2[O:27][CH2:26]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18430EpibromohydrinHCID 135731737HCID 135731737, compound

Product 1

HCID 13023013HCID 13023013, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

i. A stirred mixture of 6-chloro-3-(2-hydroxy-4-methoxyphenyl)pyridazine (0.1 mole), potassium carbonate (0.3 mole) and epibromohydrin (0.4 mole) in butan-2-one was heated under reflux overnight. The filtered solution was evaporated to give an oil which was purified by elution with mixtures of chloroform-methanol on a silica column to give 6-chloro-3-[2-(2,3-epoxypropoxy)phenyl]pyridazine.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. customThe filtered solution was evaporated
  4. customto give an oil which
  5. customwas purified by elution with mixtures of chloroform-methanol on a silica column

Sources & evidence

ORD record
ord-35d0b7c7856a4cb9ae74df3f94adaff4
Source dataset
uspto-grants-1977_10
Patent number
US04053601

Reaction notes

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