Hydrazine hydrate (1:1) → HCID 20309456, compound

HRID 972778Notes

Reaction equation

HRID 972778 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=2[O:16][CH2:17][CH:18]([OH:25])[CH2:19][NH:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:4][CH:3]=1.O.[NH2:27][NH2:28]>C(O)C>[C:21]([NH:20][CH2:19][CH:18]([OH:25])[CH2:17][O:16][C:9]1[CH:10]=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:8]=1[C:5]1[N:6]=[N:7][C:2]([NH:27][NH2:28])=[CH:3][CH:4]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20309446HCID 20309446, compound

Product 1

HCID 20309456HCID 20309456, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred mixture of 6-chloro-3-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]pyridazine and hydrazine hydrate in ethanol was heated under reflux for 3 hours. Evaporation of the reaction mixture under reduced pressure gave the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customEvaporation of the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-3f15739a30c94aeeac8d4c61a6f939b4
Source dataset
uspto-grants-1977_10
Patent number
US04053601

Reaction notes

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