Hydrochloric Acid → HCID 20309545, compound

Participants

Reaction Steps

3-[5-Amino-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]-propionic acid, prepared by hydrolysis of the product of Example 13(viii), was esterified with hydrogen chloride in methanol. Evaporation of the solution under reduced pressure gave a residue which was dissolved in the minimum quantity of water, the solution was neutralised with sodium carbonate and extracted with dichloromethane. The extract was washed with saturated brine, dried and evaporated to give methyl 3-[5-amino-2-(2-hydroxy-3-t-butylaminopropoxy)benzoyl]-propionate.

Provenance & Evidence