Hydrochloric Acid → HCID 20309545, compound

HRID 972802Notes

Reaction equation

HRID 972802 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][CH:17]([OH:24])[CH2:18][NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[C:6]([CH:14]=1)[C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8].Cl.[C:26](=O)([O-])[O-].[Na+].[Na+]>CO.O>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][CH:17]([OH:24])[CH2:18][NH:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[C:6]([CH:14]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:26])=[O:12])=[O:8]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 20309496HCID 20309496, compound

Product 1

HCID 20309545HCID 20309545, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-[5-Amino-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]-propionic acid, prepared by hydrolysis of the product of Example 13(viii), was esterified with hydrogen chloride in methanol. Evaporation of the solution under reduced pressure gave a residue which was dissolved in the minimum quantity of water, the solution was neutralised with sodium carbonate and extracted with dichloromethane. The extract was washed with saturated brine, dried and evaporated to give methyl 3-[5-amino-2-(2-hydroxy-3-t-butylaminopropoxy)benzoyl]-propionate.

Workup

  1. customEvaporation of the solution under reduced pressure
  2. customgave a residue which
  3. extractionextracted with dichloromethane
  4. washThe extract was washed with saturated brine
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-85244aa2bc3a42db9fa0ff3e90fdfe53
Source dataset
uspto-grants-1977_10
Patent number
US04053601

Reaction notes

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