Sodium Hydroxide → HCID 20309559, compound

HRID 972803Notes

Reaction equation

HRID 972803 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:28])[CH2:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][C:11]=1[C:20](=[O:27])[CH2:21][CH2:22][C:23]([O:25]C)=[O:24])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)(=O)C>[C:1]([NH:5][CH2:6][CH:7]([OH:28])[CH2:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=1[C:20](=[O:27])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20309576HCID 20309576, compound

Product 1

HCID 20309559HCID 20309559, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Methyl 4-(3-t-butylamino-2-hydroxypropoxy)-3-(3-carbomethoxypropionyl)benzoate was heated with dilute sodium hydroxide solution until hydrolysis was complete. The solution was neutralised with acetic acid then evaporated under reduced pressure. Extraction of the residue with ethanol and evaporation of the extracts gave 4-(3-t-butylamino-2-hydroxypropoxy)-3-(3-carboxypropionyl)benzoic acid.

Workup

  1. customthen evaporated under reduced pressure
  2. extractionExtraction of the residue
  3. customwith ethanol and evaporation of the extracts

Sources & evidence

ORD record
ord-86e2f7d6e55749a6b4efd84110635a18
Source dataset
uspto-grants-1977_10
Patent number
US04053601

Reaction notes

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