HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 972808Generated: October 31, 2026
Phthalic Anhydride → 1-Benzyl-4-phthalimidopiperidine
https://huagongshe.com/reaction/972808
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | 1-Benzyl-4-piperidylamine | HCID 415852 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Benzyl-4-phthalimidopiperidine | HCID 2826246 | — |
Reaction Steps
16.8 Grams of phthalic anhydride and 21.6 grams of 4-amino-1-benzyl-piperidine were stirred together while they were being heated in an oil bath at 150° C. for 30 minutes. On cooling, the resulting glassy solid was heated with 400 milliliters of methanol to give 26.5 grams of 1-benzyl-4-phthalimidopiperidine. Melting point: 154°-7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04053615 |
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| Source dataset | uspto-grants-1977_10 |
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| ORD ID | ord-343a4867e41b4f64ac4294ff0b1e5325 |
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| Source note | uspto-grants-1977_10 |
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