HCID 21405556, compound → HCID 21405566, compound

HRID 972812Notes

Reaction equation

HRID 972812 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([N:9]2[C:13](=[O:14])[C:12]3=[CH:15][C:16]([N+:19]([O-])=O)=[CH:17][CH:18]=[C:11]3[C:10]2=[O:22])[CH2:4]1)[CH3:2].[H][H]>C(O)(=O)C.[Pd]>[NH2:19][C:16]1[CH:15]=[C:12]2[C:13](=[O:14])[N:9]([CH:5]3[CH2:6][CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4]3)[C:10](=[O:22])[C:11]2=[CH:18][CH:17]=1

Participants

5

Reactant 2

HCID 21405556HCID 21405556, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21405566HCID 21405566, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

2.8 Grams of 1-ethyl-3-(4-nitrophthalimido)piperidine were dissolved in 50 milliliters of hot glacial acetic acid and were hydrogenated at 50° C. and 50 p.s.i. in the presence of 0.1 grams of 5% palladium-on-charcoal catalyst until the theoretical amount of hydrogen was taken up. The hot solution was filtered and the mixture cooled and the solid formed was filtered and dried to give 1.06 grams of the title compound in the form of the monohydrochloride.

Workup

  1. customwere hydrogenated at 50° C.
  2. filtrationThe hot solution was filtered
  3. temperaturethe mixture cooled
  4. customthe solid formed
  5. filtrationwas filtered
  6. customdried

Sources & evidence

ORD record
ord-1be336841086430ba10a7e8cdeedebbd
Source dataset
uspto-grants-1977_10
Patent number
US04053615

Reaction notes

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