反应详情

To a solution of 1.2 grams of 1-n-butyl-4-(4-nitrophthalimido) piperidine monohydrochloride in 50 milliliters of glacial acetic acid were added 0.3 grams of 5% palladium on carbon catalyst and the mixture hydrogenated at 40°-60° C. at 50 p.s.i. until the theoretical amount of hydrogen was taken up. The solution was cooled, filtered over kieselguhr and evaporated to a small volume, then triturated with ether to give the title compound as the monohydrochloride. Melting Point: 265°-270° C.

1. customhydrogenated at 40°-60° C.
2. temperatureThe solution was cooled
3. filtrationfiltered over kieselguhr
4. customevaporated to a small volume
5. customtriturated with ether