反应详情

35.7 g methyl nitroacetate was added slowly to a refluxing mixture of 39.0 g of 1A and 300 ml of isopropyl alcohol. The mixture then was refluxed for 1 hour with provision to remove the methyl mercaptan by-product. The mixture was cooled and filtered to give the methyl ester of (1-methyl-2-imidazolidinylidene)nitroacetic acid (1B) as a solid, m.p.: 214°-217° (with decomposition).

1. temperatureThe mixture then was refluxed for 1 hour with provision
2. customto remove the methyl mercaptan by-product
3. temperatureThe mixture was cooled
4. filtrationfiltered