Ethyl diethylphosphonocrotonate → Ethyl 5-(2-propyl-5-thiazolyl)2,4-pentadienoate

HRID 972837Notes

Reaction equation

[CH2:1]([C:4]1[S:5][C:6]([CH:9]=O)=[CH:7][N:8]=1)[CH2:2][CH3:3].C(OP(/[C:19](=[CH:25]\[CH3:26])/[C:20]([O:22][CH2:23][CH3:24])=[O:21])(OCC)=O)C>>[CH2:1]([C:4]1[S:5][C:6]([CH:9]=[CH:26][CH:25]=[CH:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:7][N:8]=1)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 7022350Ethyl diethylphosphonocrotonate

HCID 203698522-Propylthiazole-5-carbaldehyde

Product 1

HCID 54337588Ethyl 5-(2-propyl-5-thiazolyl)2,4-pentadienoate

Procedure

Using the procedure of Example 4, 2-propyl-5-thiazole-carboxaldehyde [prepared by reaction of manganese dioxide and 2-propyl-5-hydroxymethyl-thiazole in benzene] and ethyl diethylphosphonocrotonate were reacted to obtain ethyl 5-(2-propyl-5-thiazolyl)-2,4-pentadienoate melting at 52°C.

Workup

customwere reacted

Sources & evidence

ORD record: ord-f9c6658be54b4e6e9f4a074bf7c84924
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04053618

Reaction notes

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