Hydrochloric Acid → Methyl 6-methylnicotinate

HRID 972854Notes

Reaction equation

HRID 972854 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.Cl.[CH3:12]O>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:12])=[O:7])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1378606-Methylnicotinic acid

Product 1

HCID 231548Methyl 6-methylnicotinate

Procedure

6-Methylnicotinic acid (0.1 mole) is refluxed in 100 ml. of methanol saturated with gaseous hydrogen chloride for 1 hour and then evaporated to dryness. The residue is stirred saturated aqueous sodium bicarbonate solution and the product is extracted into chloroform. The chloroform extract is dried and concentrated to dryness to give methyl 6-methylnicotinate.

Workup

  1. customevaporated to dryness
  2. extractionthe product is extracted into chloroform
  3. extractionThe chloroform extract
  4. customis dried
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-0e05ceed66da49c9a22080d11083b8b8
Source dataset
uspto-grants-1977_10
Patent number
US04053606

Reaction notes

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