Ethanol → HCID 178460813, compound

HRID 972917Notes

Reaction equation

HRID 972917 reaction equation
[CH3:1][N:2]1[C:6]([SH:7])=[N:5][C:4]([OH:8])=[N:3]1.[CH2:9](Br)[C:10]#[CH:11].C(O)C>C(N(CC)CC)C>[CH3:1][N:2]1[C:6]([S:7][CH2:11][C:10]#[CH:9])=[N:5][C:4]([OH:8])=[N:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 7842Propargyl bromideHCID 178481959HCID 178481959, compound

Product 1

HCID 178460813HCID 178460813, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

13.1 g of 1-methyl-3-hydroxy-5-mercapto-1,2,4-triazole and 13.1 g of propargyl bromide are added to 100 ml of ethanol. To this suspension are added all at once 11.1 g of triethylamine. The exothermic reaction causes the temperature to rise to 45° C. After a short time a yellow product falls out of the clear solution and is filtered off and washed with water. The undissolved material is dried over P2O5.

Workup

  1. customThe exothermic reaction
  2. customto rise to 45° C
  3. filtrationis filtered off
  4. washwashed with water
  5. dry with materialThe undissolved material is dried over P2O5

Sources & evidence

ORD record
ord-adbb186ad1d64e358776fd9fea14cfa4
Source dataset
uspto-grants-1977_10
Patent number
US04054575

Reaction notes

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