Water → HCID 12367739, compound

HRID 972921Notes

Reaction equation

HRID 972921 reaction equation
[OH:1][N:2]1[C:11]2[C:6](=[C:7]3[S:14][C:13](=[O:15])[NH:12][C:8]3=[CH:9][CH:10]=2)[C:5](=[O:16])[C:4]([C:17]([OH:19])=[O:18])=[CH:3]1.[OH-].[K+].O.[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CO>[CH2:23]([O:1][N:2]1[C:11]2[C:6](=[C:7]3[S:14][C:13](=[O:15])[N:12]([CH2:5][C:6]4[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=4)[C:8]3=[CH:9][CH:10]=2)[C:5](=[O:16])[C:4]([C:17]([OH:19])=[O:18])=[CH:3]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7498Benzyl BromideHCID 14797Potassium HydroxideHCID 12367726HCID 12367726, compound

Product 1

HCID 12367739HCID 12367739, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 1.0 g of 2,3,6,9-tetrahydro-6-hydroxy-2,9-dioxothiazolo[5,4-f]quinoline-8-carboxylic acid, 0.96 g of an 85% - potassium hydroxide aqueous solution, 20 ml of water and 7 ml of methanol was added dropwise 2.77 g of benzyl bromide and the mixture was stirred for 44 hours at room temperature.

Sources & evidence

ORD record
ord-2e996ee441554886ae813466f68487de
Source dataset
uspto-grants-1977_10
Patent number
US04054568

Reaction notes

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