反应详情

0.7 Gm. of 2-(5,5-ethylenedioxy-5H-dibenzo[a,d]cyclohepten-2-yl)propionitrile is refluxed for 9 hours in 40 ml. of water containing 1.1 gm. of potassium hydroxide. The solution is cooled and neutralized with dilute hydrochloric acid, and extracted with ether. The ether extract is washed, dried and evaporated to afford a 75% yield of 2-(5,5-ethylenedioxy-5H-dibenzo[a,d]cyclohepten-2-yl)propionic acid. Use of 2-(5,5-ethylenedioxy)-5H-dibenzo[a,d]cyclohepten-2-yl)acetonitrile gives a similar yield of 2-(5,5-ethylenedioxy-5H-dibenzo[a,d]cyclohepten-2-yl)acetic acid.

1. temperatureThe solution is cooled
2. extractionextracted with ether
3. extractionThe ether extract
4. washis washed
5. customdried
6. customevaporated