反应详情

To a solution of 7-(1-chloro-2,6-dioxocyclohexyl)-5-heptynoic acid methyl ester (23.6 g), described in Example 14, in xylene (250 ml) is added powdered sodium carbonate (11.8 g) and the mixture stirred and heated at refluxed for 16 hr. After cooling the mixture is washed with water to neutral, dried over magnesium sulfate, and the solvent evaporated to give the crude cyclopentenone ester. Distillation of the crude ester at 0.6 mm Hg affords 7-(5-oxocyclopent-1-enyl)-5-heptynoic acid methyl ester, b.p. 142° - 156° C.

1. temperatureheated
2. temperatureat refluxed for 16 hr
3. temperatureAfter cooling the mixture
4. washis washed with water to neutral,
5. dry with materialdried over magnesium sulfate
6. customthe solvent evaporated
7. customto give the crude cyclopentenone ester
8. distillationDistillation of the crude ester at 0.6 mm Hg