Sec-Butylamine → HCID 21400873, compound

HRID 973116Notes

Reaction equation

HRID 973116 reaction equation
[CH3:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([NH:12][CH:13]([CH3:15])[CH3:14])[N:3]=1.[CH:16]([NH2:20])([CH2:18][CH3:19])[CH3:17]>C(N(CC)CC)C>[CH3:1][C:2]1[N:3]=[C:4]([NH:12][CH:13]([CH3:15])[CH3:14])[C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH:20][CH:16]([CH2:18][CH3:19])[CH3:17])[N:7]=1

Participants

4

Reactant 2

HCID 24874Sec-ButylamineHCID 3697918HCID 3697918, compound

Product 1

HCID 21400873HCID 21400873, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

10 ml of triethylamine are added to 8.05 g (0.035 mol) of 2-methyl-4-chloro-5-nitro-6-isopropylamino-pyrimidine. While cooling with ice, 7.3 g (0.1 mol) of sec- butylamine are slowly added dropwise and the mixture is stirred for 16 hours at room temperature. The reaction solution is evaporated, the residue suspended in 500 ml of water and extracted 3 times with ether, to yield 9.0 g of 2-methyl-4-isopropylamino-6-sec.-butylamino-5-nitro-pyrimidine (36.5%) as an oil.

Workup

  1. additionare slowly added dropwise
  2. customThe reaction solution is evaporated
  3. extractionextracted 3 times with ether

Sources & evidence

ORD record
ord-0e5d01ee3b944bfd9b2beda6c407a82f
Source dataset
uspto-grants-1977_10
Patent number
US04055411

Reaction notes

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