Nitric Acid → HCID 178440251, compound

HRID 973119Notes

Reaction equation

HRID 973119 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([CH:9]([CH3:11])[CH3:10])[N:3]=1.[N+:12]([O-])([OH:14])=[O:13]>>[OH:8][C:6]1[C:7]([N+:12]([O-:14])=[O:13])=[C:2]([OH:1])[N:3]=[C:4]([CH:9]([CH3:11])[CH3:10])[N:5]=1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 178440243HCID 178440243, compound

Product 1

HCID 178440251HCID 178440251, compound

Procedure

220 g of 4,6-dihydroxy-2-isopropyl-pyrimidine are added at 0° C to 500 ml of 100% nitric acid and the mixture is stirred for 1 hour. Subsequently the nitration mixture is poured on ice water, filtered, washed with water, and dried in vacuo over P2O5, to yield 110 g of 4,6-dihydroxy-2-isopropyl-5-nitro-pyrimidine; m.p. 300° C.

Workup

  1. additionSubsequently the nitration mixture is poured on ice water
  2. filtrationfiltered
  3. washwashed with water
  4. dry with materialdried in vacuo over P2O5

Sources & evidence

ORD record
ord-e906395d1c9744f5b48f62a29e9a6279
Source dataset
uspto-grants-1977_10
Patent number
US04055411

Reaction notes

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